A fungal disease that has killed more than 5.5 million bats in the eastern United States and Canada is making its way west.

What's known as "white-nose syndrome" has now been diagnosed in three Missouri bats - the first confirmed cases west of the Mississippi, and St. Louis scientists say it won’t stop there.

Since white-nose syndrome was first discovered in bats near Albany, New York, in early 2007, it has devastated bat populations in the eastern U.S..

“Unfortunately, there’s not a lot we can do to stop it,” says Tony Elliott, a scientist with the Missouri Department of Conservation, who says he knew it was only a matter of time before the disease crossed the Mississippi River into Missouri.

That’s because white-nose syndrome is caused by a fungus that easily passes from bat to bat. The disease is named for the powdery white growth that can sometimes coat an infected bat’s muzzle and wings. The fungus penetrates the bat’s skin, eating away at the thin, semi-translucent membranes of its wings, tail, and ears.

But, there’s still plenty scientiests don’t know about the disease.

“It is still a bit of a mystery exactly what the ultimate cause of death is,” Elliott says.

What is clear is that the fungus is changing the bats’ behavior.

“In heavily infected sites, the bats roost in odd locations," Elliott says, "often near the entrance of the site, and will be seen flying out of the site in the middle of the day, in the middle of the winter sometimes, when there’s obviously no good reason for them to be flying out and around.”

Scientists have a number of theories about why the bats are dying. They may be using up their winter fat reserves too soon and starving to death. Bats that go out in the daytime make easy pickings for predators. They might be dying from the cold. And since bats regulate water loss through their wings, the flesh-eating fungus could cause deadly dehydration.

Some species have been hit harder than others. The once-common little brown bat has seen its northeastern populations plummet. Five other species have also been affected.

“We are basically monitoring and watching one of the greatest population declines through disease that’s ever been recorded for a mammal species, and that is certainly of concern, to put it mildly,” says Jeremy Coleman, national white-nose syndrome coordinator for the U.S. Fish and Wildlife Service.

Now that white-nose has crossed the Mississippi, he believes it will likely spread throughout the Midwest,  and not just westward.

“This past winter we did see white nose confirmed in northeastern Alabama, which is also disconcerting, especially given the fact that this winter was very warm, uncharacteristically so,” Coleman says.

Some scientists had hoped the cold-loving fungus that causes white-nose syndrome wouldn't be able to survive so far south.

It’s not clear what the loss of so many bats will mean for the environment. Tony Elliott says bat guano provides nutrients to cave ecosystems. And bats eat a lot of insects - many of them pests on forests and crops.

“We estimate that there may be 800,000 to a million gray bats living in Missouri," he says. "And doing the math out, that could lead to over 540 tons of insects eaten per year by just that one species in Missouri.”

Without bats, those insects could become a costly headache for farmers.

So far, there’s no way to treat white-nose syndrome, or stop it from spreading from bat to bat. According to Elliott, the only thing we can do is limit access to public caves, and have people who do go caving disinfect their clothes and gear.

White-nose syndrome has already reached 19 states. And scientists expect it to keep going.